Intracoronary Imaging, Cholesterol Efflux, and Transcriptomes after Intensive Statin Treatment: The YELLOW II study

Abstract Background Despite the extensive evidence for the beneficial effects of statins on clinical outcomes, the mechanisms underlying these effects in remain elusive. Objectives To assess the changes in plaque morphology by intravascular imaging with a comprehensive evaluation of cholesterol effl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American College of Cardiology 2017-02, Vol.69 (6), p.628-640
Hauptverfasser:	Kini, Annapoorna S., MD, Vengrenyuk, Yuliya, PhD, Shameer, Khader, PhD, Maehara, Akiko, MD, Purushothaman, Meerarani, PhD, Yoshimura, Takahiro, MD, Matsumura, Mitsuaki, BS, Aquino, Melissa, MS, Haider, Nezam, PhD, Johnson, Kipp W., BS, Readhead, Ben, MBBS, Kidd, Brian A., PhD, Feig, Jonathan E., MD, PhD, Krishnan, Prakash, MD, Sweeny, Joseph, MD, Mahajan, Milind, PhD, Moreno, Pedro, MD, Mehran, Roxana, MD, Kovacic, Jason C., MD, PhD, Baber, Usman, MD, Dudley, Joel T., PhD, Narula, Jagat, MD, PhD, Sharma, Samin, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoproteins Cardiology Cardiovascular Cardiovascular disease Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - therapy Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Internal Medicine Leukocytes, Mononuclear Lipids Low density lipoprotein Male Multimodal Imaging Percutaneous Coronary Intervention Plaque, Atherosclerotic - blood Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - therapy Prospective Studies Rosuvastatin Calcium - therapeutic use Statins Studies Tomography, Optical Coherence Transcriptome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Background Despite the extensive evidence for the beneficial effects of statins on clinical outcomes, the mechanisms underlying these effects in remain elusive. Objectives To assess the changes in plaque morphology by intravascular imaging with a comprehensive evaluation of cholesterol efflux capacity (CEC) and peripheral blood mononuclear cells (PBMC) transcriptomics in patients receiving high-dose statin therapy. Methods In a prospective study, 85 patients with stable multivessel coronary artery disease underwent percutaneous coronary intervention for a culprit lesion followed by intracoronary multi-modality imaging including optical coherence tomography (OCT) of an obstructive non-culprit lesion (NCL). All subjects received 40 mg of rosuvastatin every day for 8-12 weeks, when the NCL was reimaged and intervention was performed. Blood samples were drawn at both times to assess cholesterol CEC and transcriptomic profile in PBMC. Results Baseline OCT minimal fibrous cap thickness (FCT) was 100.9 ± 41.7 μm and CEC 0.81 ± 0.14, which increased upon follow-up-FCT (108.6 ± 39.6 μm, P
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2016.10.029