SA4Ag, a 4-antigen Staphylococcus aureus vaccine, rapidly induces high levels of bacteria-killing antibodies

Highlights • A 4-antigen S. aureus vaccine (SA4Ag) targeting multiple virulence factors. • A Phase 1 study after finalizing manufacturing process prior to an efficacy study. • SA4Ag was well tolerated with a satisfactory safety profile in adults 18–

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2017-02, Vol.35 (8), p.1132-1139
Hauptverfasser:	Begier, Elizabeth, Seiden, David Joshua, Patton, Michael, Zito, Edward, Severs, Joseph, Cooper, David, Eiden, Joseph, Gruber, William C, Jansen, Kathrin U, Anderson, Annaliesa S, Gurtman, Alejandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Allergy and Immunology Antibodies, Bacterial - blood Antigens Antigens, Bacterial - administration & dosage Antigens, Bacterial - chemistry Antigens, Bacterial - immunology Bacteria Blood & organ donations Capsule polysaccharide Clinical trials Clumping factor A Coagulase - administration & dosage Coagulase - biosynthesis Coagulase - genetics Diaries Female Functional antibodies Healthy Volunteers Humans Immunization Immunoassay Immunogenicity Immunogenicity, Vaccine Immunoglobulins Injections, Intramuscular Male Manganese Manganese transporter C Manufacturing industry Middle Aged Pain Patient Safety Periplasmic Binding Proteins - administration & dosage Periplasmic Binding Proteins - biosynthesis Periplasmic Binding Proteins - genetics Polysaccharides, Bacterial - administration & dosage Polysaccharides, Bacterial - chemistry Polysaccharides, Bacterial - immunology Proteins R&D Recombinant Proteins - administration & dosage Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Research & development Serogroup Staphylococcal Infections - prevention & control Staphylococcal Vaccines - administration & dosage Staphylococcal Vaccines - biosynthesis Staphylococcal Vaccines - genetics Staphylococcus aureus Staphylococcus aureus - chemistry Staphylococcus aureus - immunology Staphylococcus infections Surgical site infection Vaccination Vaccine Vaccines Vaccines, Conjugate
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Beschreibung
Zusammenfassung:	Highlights • A 4-antigen S. aureus vaccine (SA4Ag) targeting multiple virulence factors. • A Phase 1 study after finalizing manufacturing process prior to an efficacy study. • SA4Ag was well tolerated with a satisfactory safety profile in adults 18–
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2017.01.024