Resveratrol Protects Against Spinal Cord Injury by Activating Autophagy and Inhibiting Apoptosis Mediated by the SIRT1/AMPK Signaling Pathway

Highlights • Resveratrol treatment ameliorates rehabilitation of motor function after spinal cord injury. • Resveratrol increases the survival of motor neurons and reduces the size of injury after spinal cord injury. • Resveratrol up-regulates SIRT1/AMPK signaling pathway and promotes autophagy after spinal cord injury. • Resveratrol inhibits apoptosis in spinal cord injury rats. • Inhibition of SIRT1/AMPK signaling pathway decreases expression level of autophagy and increases apoptosis.