In-vivo regulation of Krüppel-like factor 9 by corticosteroids and their receptors across tissues in tadpoles of Xenopus tropicalis

Highlights • Brain, lung, and tail express klf9 and type-I and type-II receptors. • Exogenous corticosterone and aldosterone can induce kfl9 in each tissue. • Both corticosteroids use type-II and not type-I receptors to induce klf9. • Only corticosterone/type-II receptor induces klf9 in-vivo....

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Veröffentlicht in:	General and comparative endocrinology 2017-07, Vol.248, p.79-86
Hauptverfasser:	Shewade, Leena H, Schneider, Katelin A, Brown, Audrey C, Buchholz, Daniel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone Aldosterone - pharmacology Amphibian metamorphosis Animals Corticosterone Corticosterone - pharmacology Endocrinology & Metabolism Female Gene Expression Profiling Gene Expression Regulation, Developmental - drug effects Glucocorticoid receptor Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Larva - drug effects Larva - genetics Male Mice Mineralocorticoid receptor Receptors, Steroid - antagonists & inhibitors Receptors, Steroid - metabolism RU486 Spironolactone Time Factors Xenopus - metabolism Xenopus Proteins - genetics Xenopus Proteins - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Brain, lung, and tail express klf9 and type-I and type-II receptors. • Exogenous corticosterone and aldosterone can induce kfl9 in each tissue. • Both corticosteroids use type-II and not type-I receptors to induce klf9. • Only corticosterone/type-II receptor induces klf9 in-vivo.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2017.02.007