Synthesis of Ring-Fused 1‑Benzazepines via [1,5]-Hydride Shift/7-Endo Cyclization Sequences

Synthesis of Ring-Fused 1‑Benzazepines via [1,5]-Hydride Shift/7-Endo Cyclization Sequences

Synthesis of 1-benzazepines has been achieved via a [1,5]-hydride shift/7-endo cyclization sequence. The focus of this research is a direct transformation of 2-(aryl)­cyclopropane 1,1-diester derivatives into 1-benzazepines using a cyclopropane moiety as the hydride acceptor in internal redox reacti...

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Veröffentlicht in:Organic letters 2017-03, Vol.19 (6), p.1334-1337
Hauptverfasser: Suh, Chang Won, Kwon, Su Jin, Kim, Dae Young
Format: Artikel
Sprache:eng
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Zusammenfassung:Synthesis of 1-benzazepines has been achieved via a [1,5]-hydride shift/7-endo cyclization sequence. The focus of this research is a direct transformation of 2-(aryl)­cyclopropane 1,1-diester derivatives into 1-benzazepines using a cyclopropane moiety as the hydride acceptor in internal redox reactions.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b00184