Significance of immune checkpoint proteins in EGFR -mutant non-small cell lung cancer

Highlights • Casesof advanced stage EGFR mutant NSCLC were analysed. • PD-L1, PD-1, CTLA-4 and TIM3 expression were characterized. • High tumor PD-L1 had a shorter PFS. • Immune cell CTLA-4 expression was prognostic.

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-03, Vol.105, p.17-22
Hauptverfasser:	Soo, Ross A, Kim, Hye Ryun, Asuncion, Bernadette Reyna, Fazreen, Zul, Omar, Mohamed Feroz Mohd, Herrera, Maria Cynthia, Yun Lim, Joey Sze, Sia, Grace, Soong, Richie, Cho, Byoung-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over B7-H1 Antigen - metabolism Biomarkers, Tumor - metabolism Carcinoma, Non-Small-Cell Lung - genetics CD3 Complex - metabolism CTLA-4 Antigen - metabolism Cytotoxic T-lymphocyte antigen-4 Epidermal growth factor receptor mutations Female Hematology, Oncology and Palliative Medicine Hepatitis A Virus Cellular Receptor 2 - metabolism Humans Lung Neoplasms - genetics Male Middle Aged Mutation Non-small cell lung cancer Programmed Cell Death 1 Receptor - metabolism Programmed death ligand-1 Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - therapeutic use Pulmonary/Respiratory Receptor, Epidermal Growth Factor - genetics Survival Analysis T-cell immunoglobulin and mucin-domain containing-3 Treatment Outcome
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Beschreibung
Zusammenfassung:	Highlights • Casesof advanced stage EGFR mutant NSCLC were analysed. • PD-L1, PD-1, CTLA-4 and TIM3 expression were characterized. • High tumor PD-L1 had a shorter PFS. • Immune cell CTLA-4 expression was prognostic.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2017.01.008