Serum levels of brain-derived neurotrophic factor are associated with depressive symptoms in patients with systemic lupus erythematosus

Serum levels of brain-derived neurotrophic factor are associated with depressive symptoms in patients with systemic lupus erythematosus

Highlights • BDNF is deeply related to pathogenesis of depression. • The serum BDNF levels are lower in SLE patients with depression than those without. • Serum BNDF levels are independently associated with depressive symptoms in SLE. • The data suggests the role of neurotrophic factors in depressio...

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Veröffentlicht in:Psychoneuroendocrinology 2017-04, Vol.78, p.246-252
Hauptverfasser: Zheng, Qing, Xu, Ming-Jun, Cheng, Jing, Chen, Jun-Min, Zheng, Ling, Li, Zhan-Guo
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Biomarkers
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Chinese
Depression - blood
Depression - complications
Depressive symptoms
Endocrinology & Metabolism
Female
Humans
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - complications
Male
Middle Aged
Psychiatry
Systemic lupus erythematosus
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Zusammenfassung:Highlights • BDNF is deeply related to pathogenesis of depression. • The serum BDNF levels are lower in SLE patients with depression than those without. • Serum BNDF levels are independently associated with depressive symptoms in SLE. • The data suggests the role of neurotrophic factors in depression.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.12.001