Organocatalytic Asymmetric Tamura Cycloaddition with α- Branched Nitroolefins: Synthesis of Functionalized 1‑Tetralones
A new catalytic asymmetric Tamura cycloaddition with nitroolefins was developed. This demonstration of the reaction of α-branched nitroolefins with homophthalic anhydrides delivers highly functionalized 1-tetralone compounds. With bifunctional squaramide catalyst, the desired tetralone products are...
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| Veröffentlicht in: | Journal of organic chemistry 2017-03, Vol.82 (6), p.3262-3269 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A new catalytic asymmetric Tamura cycloaddition with nitroolefins was developed. This demonstration of the reaction of α-branched nitroolefins with homophthalic anhydrides delivers highly functionalized 1-tetralone compounds. With bifunctional squaramide catalyst, the desired tetralone products are obtained with high enantioselectivity and good diastereoselectivity. |
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| ISSN: | 0022-3263 1520-6904 |
| DOI: | 10.1021/acs.joc.6b03020 |