Synergic activity of fluoroquinolones and linezolid against Mycobacterium tuberculosis

We evaluated the in vitro activity against Mycobacterium tuberculosis of the combination of fluoroquinolones and linezolid with classical drugs. The combination of isoniazid with fluoroquinolones had synergic activity in nine of the ten isoniazid-susceptible strains. We also found synergism between...

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Veröffentlicht in:	International journal of antimicrobial agents 2003-04, Vol.21 (4), p.354-356
Hauptverfasser:	Rodriguez Dı́az, Juan Carlos, Ruiz, M., López, M., Royo, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - chemistry Acetamides - pharmacology Anti-Bacterial Agents Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Chemotherapy Drug Resistance, Multiple, Bacterial Drug Synergism Drug Therapy, Combination - pharmacology Fluoroquinolones In Vitro Techniques Linezolid M. tuberculosis Medical sciences Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Oxazolidinones - chemistry Oxazolidinones - pharmacology Pharmacology. Drug treatments Synergy Tuberculosis - microbiology
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Zusammenfassung:	We evaluated the in vitro activity against Mycobacterium tuberculosis of the combination of fluoroquinolones and linezolid with classical drugs. The combination of isoniazid with fluoroquinolones had synergic activity in nine of the ten isoniazid-susceptible strains. We also found synergism between rifampicin and linezolid in five of the 15 strains susceptible to rifampicin. The clinical significance of these findings should be evaluated.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/S0924-8579(02)00387-4