Fviia Prevents The Progressive Hemorrhaging Of A Brain Contusion By Protecting Microvessels Via Formation Of The Tf- Fviia-Fxa Complex

Highlights • The decrease of FⅦ activity is closely related to the increase of brain contusion hemorrhage size. • FⅦa prevent the progressive hemorrhaging of brain contusions by protecting. • microvessel endothelial cells. • Ternary TF-FⅦa-FXa protect endothelial cells through activating p44/42 MAPK...

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Veröffentlicht in:	Neuroscience 2017-04, Vol.348, p.114-125
Hauptverfasser:	Yuan, Qiang, Zhang, Dalong, Wu, Sirong, Yu, Jian, Yu, Lei, Sun, Yirui, Du, Zhuoying, Li, Zhiqi, Zhou, Liangfu, Wu, Xing, Hu, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects brain contusion Disease Models, Animal endothelial cell Extracellular Signal-Regulated MAP Kinases - metabolism Factor VIIa - pharmacology Factor VIIa - therapeutic use FVIIa Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Intracranial Hemorrhages - drug therapy Intracranial Hemorrhages - metabolism Mice Microvessels - drug effects Neurology NF-kappa B - metabolism progressive hemorrhage Receptor, PAR-2 - metabolism Signal Transduction - drug effects TF–FVIIa–FXa complex
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Zusammenfassung:	Highlights • The decrease of FⅦ activity is closely related to the increase of brain contusion hemorrhage size. • FⅦa prevent the progressive hemorrhaging of brain contusions by protecting. • microvessel endothelial cells. • Ternary TF-FⅦa-FXa protect endothelial cells through activating p44/42 MAPK and inhibiting p65 NF-κB signaling pathway.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.02.020