Immunoprofiling as a predictor of patient’s response to cancer therapy—promises and challenges

Highlights • T cell type, number and location (Immunoscore) in colon cancer predicts prognosis. • Colon cancer Immunoscore predicted prognosis is superior to AJCC TNM staging. • Tumor PD-L1 expression allows enrichment of patients who respond to anti-PD-1. • Multispectral IHC imaging allows for eval...

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Veröffentlicht in:	Current opinion in immunology 2017-04, Vol.45, p.60-72
Hauptverfasser:	Bethmann, Daniel, Feng, Zipei, Fox, Bernard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals B7-H1 Antigen - immunology Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - therapy Colonic Neoplasms - immunology Colonic Neoplasms - pathology Colonic Neoplasms - therapy Gene Expression Profiling Gene Expression Regulation, Neoplastic - immunology Humans Lung Neoplasms - immunology Lung Neoplasms - pathology Lung Neoplasms - therapy Neoplasm Proteins - immunology
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Beschreibung
Zusammenfassung:	Highlights • T cell type, number and location (Immunoscore) in colon cancer predicts prognosis. • Colon cancer Immunoscore predicted prognosis is superior to AJCC TNM staging. • Tumor PD-L1 expression allows enrichment of patients who respond to anti-PD-1. • Multispectral IHC imaging allows for evaluation of cell-to-cell spatial relationships. • Expect stain automation to allow Multispectral IHC use for clinical decision making.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2017.01.005