TRANSCRIPTOMIC ANALYSIS REVEALS DIFFERENTIAL ACTIVATION OF MICROGLIAL GENES AFTER ISCHEMIC STROKE IN MICE

Highlights • Digital gene expression of ischemic tissue after photothrombosis. • Larger microglial genes were altered at 2 days as compared to 7 days after stroke in response to ischemia. • Over 74% genes were identified as microglial genes after ischemia. • Pathways analysis revealed novel informat...

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Veröffentlicht in:	Neuroscience 2017-04, Vol.348, p.212-227
Hauptverfasser:	Khan, Akbar, Ju, Furong, Xie, Wenguang, Tariq Hafeez, Muhammad, Cheng, Xiaofeng, Yang, Zhijie, Zhu, Lirui, Li, Ting, Zy, Shengxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Animals Brain Ischemia - genetics Brain Ischemia - metabolism Brain Ischemia - pathology digital gene expression Down-Regulation Gene Expression Profiling Male Mice microglia Microglia - metabolism Microglia - pathology Neurology photothrombosis stroke Stroke - genetics Stroke - metabolism Stroke - pathology Transcriptome Up-Regulation
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Zusammenfassung:	Highlights • Digital gene expression of ischemic tissue after photothrombosis. • Larger microglial genes were altered at 2 days as compared to 7 days after stroke in response to ischemia. • Over 74% genes were identified as microglial genes after ischemia. • Pathways analysis revealed novel information of up- and down regulated genes in progression of ischemia.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.02.019