Steady-state centrifugal input via the lateral olfactory tract modulates spontaneous activity in the rat main olfactory bulb

Highlights • Topical lidocaine application selectively inhibits tonic action potential conduction in the lateral olfactory tract (LOT). • The rate of spontaneous activity of glomerular layer units and mitral cell units was significantly dampened by LOT block. • Tonic inhibitory and excitatory drive...

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Veröffentlicht in:	Neuroscience 2017-04, Vol.348, p.165-179
Hauptverfasser:	Ford, Neil C, Griff, Edwin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Anesthetics, Local - pharmacology Animals centrifugal input lateral olfactory tract Lidocaine - pharmacology main olfactory bulb Male Neurology Neurons - drug effects Neurons - physiology Olfactory Bulb - drug effects Olfactory Bulb - physiology Olfactory Pathways - drug effects Olfactory Pathways - physiology Rats spontaneous activity Synaptic Transmission - drug effects Synaptic Transmission - physiology
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Zusammenfassung:	Highlights • Topical lidocaine application selectively inhibits tonic action potential conduction in the lateral olfactory tract (LOT). • The rate of spontaneous activity of glomerular layer units and mitral cell units was significantly dampened by LOT block. • Tonic inhibitory and excitatory drive to the MOB via the LOT dynamically shape the spontaneous activity of MOB neurons.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.02.013