The Functional Stability of FOXP3 and RORγt in Treg and Th17 and Their Therapeutic Applications

The balance of CD4 CD25 FOXP3 regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imbalance of them is related to many inflammatory diseases in both human and mice. Here we discuss about the plasticity of Tregs and Th17 cells, and the related...

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Veröffentlicht in:	Advances in protein chemistry and structural biology 2017, Vol.107, p.155-189
Hauptverfasser:	Ren, J, Li, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Forkhead Transcription Factors - metabolism Forkhead Transcription Factors - therapeutic use Humans Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Nuclear Receptor Subfamily 1, Group F, Member 3 - therapeutic use Protein Stability T-Lymphocytes, Regulatory - metabolism Th17 Cells - metabolism
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Zusammenfassung:	The balance of CD4 CD25 FOXP3 regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imbalance of them is related to many inflammatory diseases in both human and mice. Here we discuss about the plasticity of Tregs and Th17 cells, and the related human diseases resulted from the imbalance of them. Further, we will focus on the mechanisms regulating the plasticity between Tregs and Th17 cells and the potential therapeutic strategies by targeting regulators of the expression and activity of FOXP3 and RORγt or regulators of Treg/Th17 balance in autoimmune diseases, allergy, infection, and cancer.
ISSN:	1876-1623
DOI:	10.1016/bs.apcsb.2016.10.002