Dynamic organization of mitotic chromosomes

Highlights • State-of-the-art technologies provide new insights into chromosome organization. • Mitotic chromatids can be reconstituted in vitro using only six purified factors. • HEAT subunits of condensin I are essential for chromosome axis assembly. • Mutations in condensin subunits cause microce...

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Veröffentlicht in:	Current opinion in cell biology 2017-06, Vol.46, p.46-53
Hauptverfasser:	Kinoshita, Kazuhisa, Hirano, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - metabolism Animals Chromatids - chemistry Chromatids - metabolism Chromosomes - chemistry Chromosomes - metabolism DNA - chemistry DNA - metabolism DNA Topoisomerases, Type II - chemistry DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Histones - chemistry Histones - metabolism Humans Internal Medicine Mitosis Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Nucleosomes - chemistry Nucleosomes - metabolism
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Beschreibung
Zusammenfassung:	Highlights • State-of-the-art technologies provide new insights into chromosome organization. • Mitotic chromatids can be reconstituted in vitro using only six purified factors. • HEAT subunits of condensin I are essential for chromosome axis assembly. • Mutations in condensin subunits cause microcephaly and promote tumorigenesis. • Interphase TADs may be linked to cytological bands on mitotic chromosomes.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/j.ceb.2017.01.006