Determinants of cough effectiveness in patients with respiratory muscle weakness

Highlights • Cough’s goal is to generate high intrathoracic pressure during brief glottic closure. • Absent muscle weakness, glottic closure is not necessary for effective cough. • With muscle weakness, cough is effective only if accompanied by glottic closure. • Impaired glottic closure contributes...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2017-06, Vol.240, p.17-25
Hauptverfasser:	Laghi, Franco, Maddipati, Veeranna, Schnell, Timothy, Langbein, W. Edwin, Tobin, Martin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal muscles Abdominal Muscles - physiopathology Adult Aged Analysis of Variance Cough - diagnosis Cough - etiology Electric Stimulation - methods Electromyography Exhalation Female Glottis Glottis - physiopathology Humans Male Medical Education Middle Aged Muscle Weakness - complications Muscle Weakness - etiology Muscle Weakness - pathology Neuromuscular electrical stimulation Pulmonary/Respiratory Respiratory Muscles - physiopathology Spinal Cord Injuries - complications Spinal cord injury Total Lung Capacity - physiology Tracheostomy
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Zusammenfassung:	Highlights • Cough’s goal is to generate high intrathoracic pressure during brief glottic closure. • Absent muscle weakness, glottic closure is not necessary for effective cough. • With muscle weakness, cough is effective only if accompanied by glottic closure. • Impaired glottic closure contributes to ineffective cough in bulbar disorders. • Impaired glottic closure contributes to ineffective cough in tracheostomized patients.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2017.02.005