High glucose-induced oxidative stress and mitochondrial dysfunction in neurons

High glucose-induced oxidative stress and mitochondrial dysfunction in neurons

The current study examines the association between glucose induction of reactive oxygen species (ROS), mitochondrial (Mt) depolarization, and programmed cell death in primary neurons. In primary dorsal root ganglion (DRG) neurons, 45 mM glucose rapidly induces a peak rise in ROS corresponding to a 5...

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Veröffentlicht in:The FASEB journal 2002-08, Vol.16 (10), p.1738-1748
Hauptverfasser: Russell, J W, Golovoy, D, Vincent, A M, Mahendru, P, Olzmann, JA, Mentzer, A, Feldman, EL
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Sprache:eng
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Zusammenfassung:The current study examines the association between glucose induction of reactive oxygen species (ROS), mitochondrial (Mt) depolarization, and programmed cell death in primary neurons. In primary dorsal root ganglion (DRG) neurons, 45 mM glucose rapidly induces a peak rise in ROS corresponding to a 50% increase in mean Mt size at 6 h (P
ISSN:0892-6638