Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis
Breakthrough invasive mold infections (IMIs) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. This retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift tow...
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Veröffentlicht in: | Clinical infectious diseases 2017-06, Vol.64 (11), p.1619-1621 |
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creator | Lamoth, Frederic Chung, Shimin J. Damonti, Lauro Alexander, Barbara D. |
description | Breakthrough invasive mold infections (IMIs) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. This retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift towards non-Aspergillus molds with a significantly increased proportion of rare multidrug-resistant molds. |
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This retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift towards non-Aspergillus molds with a significantly increased proportion of rare multidrug-resistant molds.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/cix130</identifier><identifier>PMID: 28199491</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adult ; Antifungal agents ; Antifungal Agents - administration & dosage ; Antifungal Agents - pharmacology ; Aspergillosis - epidemiology ; Aspergillosis - prevention & control ; Azoles - administration & dosage ; Azoles - pharmacology ; BRIEF REPORT ; Drug Resistance, Fungal ; Epidemiology ; Female ; Fungal infections ; Fungi - drug effects ; Fungi - pathogenicity ; Humans ; Invasive Fungal Infections - epidemiology ; Invasive Fungal Infections - microbiology ; Invasive Fungal Infections - mortality ; Invasive Fungal Infections - prevention & control ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Mold ; Mucormycosis - epidemiology ; Mucormycosis - prevention & control ; Multidrug resistance ; Multidrug resistant organisms ; Patients ; Posaconazole ; Prophylaxis ; Retrospective Studies ; Voriconazole</subject><ispartof>Clinical infectious diseases, 2017-06, Vol.64 (11), p.1619-1621</ispartof><rights>Copyright © 2017 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford University Press, UK Jun 1, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-defee5482bbd4f40cb0cb0f5fbb42fd7e160f83f194e1769148f748d603d5c623</citedby><cites>FETCH-LOGICAL-c373t-defee5482bbd4f40cb0cb0f5fbb42fd7e160f83f194e1769148f748d603d5c623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26374626$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26374626$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28199491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lamoth, Frederic</creatorcontrib><creatorcontrib>Chung, Shimin J.</creatorcontrib><creatorcontrib>Damonti, Lauro</creatorcontrib><creatorcontrib>Alexander, Barbara D.</creatorcontrib><title>Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Breakthrough invasive mold infections (IMIs) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. This retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift towards non-Aspergillus molds with a significantly increased proportion of rare multidrug-resistant molds.</description><subject>Adult</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - pharmacology</subject><subject>Aspergillosis - epidemiology</subject><subject>Aspergillosis - prevention & control</subject><subject>Azoles - administration & dosage</subject><subject>Azoles - pharmacology</subject><subject>BRIEF REPORT</subject><subject>Drug Resistance, Fungal</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Fungi - drug effects</subject><subject>Fungi - pathogenicity</subject><subject>Humans</subject><subject>Invasive Fungal Infections - epidemiology</subject><subject>Invasive Fungal Infections - microbiology</subject><subject>Invasive Fungal Infections - mortality</subject><subject>Invasive Fungal Infections - prevention & control</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Mold</subject><subject>Mucormycosis - epidemiology</subject><subject>Mucormycosis - prevention & control</subject><subject>Multidrug resistance</subject><subject>Multidrug resistant organisms</subject><subject>Patients</subject><subject>Posaconazole</subject><subject>Prophylaxis</subject><subject>Retrospective Studies</subject><subject>Voriconazole</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFFLwzAQgIMoTqcvvisFX0SoJk2aJo9jTB1MHKIPPpW2uWwZXTObdmz-ejM6FYTLJeG-O44PoQuC7wiW9L4wyp8NofgAnZCYJiGPJTn0bxyLkAkqeujUuQXGhAgcH6NeJIiUTJIT9DGcZ9XMVLNgtDIKlsaWdrYNrA7G1TpzZg3Bsy2V_2koGmMrF5gqmGaNgapxwSsUYNa79sGXLSGY1nY135bZxrgzdKSz0sH5_u6j94fR2_ApnLw8joeDSVjQhDahAg0QMxHluWKa4SLfhY51nrNIqwQIx1pQTSQDknBJmNAJE4pjquKCR7SPbrq5q9p-tuCadGlcAWWZVWBblxLBJeaJFNSj1__QhW3rym-XEokFxcwb8tRtRxW1da4Gna5qs8zqbUpwuhOeeuFpJ9zDV_uRbb4E9Yv-GPbAZQcsXGPrvzqnCeM-fwO9xYZc</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Lamoth, Frederic</creator><creator>Chung, Shimin J.</creator><creator>Damonti, Lauro</creator><creator>Alexander, Barbara D.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis</title><author>Lamoth, Frederic ; Chung, Shimin J. ; Damonti, Lauro ; Alexander, Barbara D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-defee5482bbd4f40cb0cb0f5fbb42fd7e160f83f194e1769148f748d603d5c623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Antifungal Agents - pharmacology</topic><topic>Aspergillosis - epidemiology</topic><topic>Aspergillosis - prevention & control</topic><topic>Azoles - administration & dosage</topic><topic>Azoles - pharmacology</topic><topic>BRIEF REPORT</topic><topic>Drug Resistance, Fungal</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fungal infections</topic><topic>Fungi - drug effects</topic><topic>Fungi - pathogenicity</topic><topic>Humans</topic><topic>Invasive Fungal Infections - epidemiology</topic><topic>Invasive Fungal Infections - microbiology</topic><topic>Invasive Fungal Infections - mortality</topic><topic>Invasive Fungal Infections - prevention & control</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Mold</topic><topic>Mucormycosis - epidemiology</topic><topic>Mucormycosis - prevention & control</topic><topic>Multidrug resistance</topic><topic>Multidrug resistant organisms</topic><topic>Patients</topic><topic>Posaconazole</topic><topic>Prophylaxis</topic><topic>Retrospective Studies</topic><topic>Voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lamoth, Frederic</creatorcontrib><creatorcontrib>Chung, Shimin J.</creatorcontrib><creatorcontrib>Damonti, Lauro</creatorcontrib><creatorcontrib>Alexander, Barbara D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lamoth, Frederic</au><au>Chung, Shimin J.</au><au>Damonti, Lauro</au><au>Alexander, Barbara D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>64</volume><issue>11</issue><spage>1619</spage><epage>1621</epage><pages>1619-1621</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Breakthrough invasive mold infections (IMIs) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. 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source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
subjects | Adult Antifungal agents Antifungal Agents - administration & dosage Antifungal Agents - pharmacology Aspergillosis - epidemiology Aspergillosis - prevention & control Azoles - administration & dosage Azoles - pharmacology BRIEF REPORT Drug Resistance, Fungal Epidemiology Female Fungal infections Fungi - drug effects Fungi - pathogenicity Humans Invasive Fungal Infections - epidemiology Invasive Fungal Infections - microbiology Invasive Fungal Infections - mortality Invasive Fungal Infections - prevention & control Male Microbial Sensitivity Tests Middle Aged Mold Mucormycosis - epidemiology Mucormycosis - prevention & control Multidrug resistance Multidrug resistant organisms Patients Posaconazole Prophylaxis Retrospective Studies Voriconazole |
title | Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis |
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