Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis

Breakthrough invasive mold infections (IMIs) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. This retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift tow...

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Veröffentlicht in:Clinical infectious diseases 2017-06, Vol.64 (11), p.1619-1621
Hauptverfasser: Lamoth, Frederic, Chung, Shimin J., Damonti, Lauro, Alexander, Barbara D.
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container_end_page 1621
container_issue 11
container_start_page 1619
container_title Clinical infectious diseases
container_volume 64
creator Lamoth, Frederic
Chung, Shimin J.
Damonti, Lauro
Alexander, Barbara D.
description Breakthrough invasive mold infections (IMIs) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. This retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift towards non-Aspergillus molds with a significantly increased proportion of rare multidrug-resistant molds.
doi_str_mv 10.1093/cid/cix130
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source Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Adult
Antifungal agents
Antifungal Agents - administration & dosage
Antifungal Agents - pharmacology
Aspergillosis - epidemiology
Aspergillosis - prevention & control
Azoles - administration & dosage
Azoles - pharmacology
BRIEF REPORT
Drug Resistance, Fungal
Epidemiology
Female
Fungal infections
Fungi - drug effects
Fungi - pathogenicity
Humans
Invasive Fungal Infections - epidemiology
Invasive Fungal Infections - microbiology
Invasive Fungal Infections - mortality
Invasive Fungal Infections - prevention & control
Male
Microbial Sensitivity Tests
Middle Aged
Mold
Mucormycosis - epidemiology
Mucormycosis - prevention & control
Multidrug resistance
Multidrug resistant organisms
Patients
Posaconazole
Prophylaxis
Retrospective Studies
Voriconazole
title Changing Epidemiology of Invasive Mold Infections in Patients Receiving Azole Prophylaxis
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