Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds

Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug development for malaria chemotherapy.

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Bibliographische Detailangaben
Veröffentlicht in:	International Journal for Parasitology 2002-12, Vol.32 (13), p.1661-1667
Hauptverfasser:	Borstnik, Kristina, Paik, Ik-hyeon, Shapiro, Theresa A, Posner, Gary H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - pharmacology Artemisinin Artemisinins - pharmacology Bridged Bicyclo Compounds, Heterocyclic - pharmacology Chemotherapy Drug Design Malaria Peroxides Plasmodium Plasmodium - drug effects Rational design of drugs Sesquiterpenes - pharmacology Trioxanes Yingzhaosu A
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Beschreibung
Zusammenfassung:	Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug development for malaria chemotherapy.
ISSN:	0020-7519 1879-0135
DOI:	10.1016/S0020-7519(02)00195-9