Two new polyketides from the ascomycete fungus Leptosphaeria sp
Leptosphaerins H and I ( 1 and 2 ), two new xanthone derivatives, and six known compounds, leptosphaerin F ( 3 ), monodictysin B ( 4 ), norlichexanthone ( 5 ), leptosphaerin D ( 6 ), moniliphenone ( 7 ) and emodinbianthrone ( 8 ) have been isolated from a scale-up fermentation of the ascomycete fung...
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| Veröffentlicht in: | Journal of antibiotics 2017-06, Vol.70 (6), p.743-746 |
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| container_title | Journal of antibiotics |
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| creator | Lin, Jie Wang, Renlei Xu, Guohua Ding, Zhengfeng Zhu, Xueshen Li, Erwei Liu, Ling |
| description | Leptosphaerins H and I (
1
and
2
), two new xanthone derivatives, and six known compounds, leptosphaerin F (
3
), monodictysin B (
4
), norlichexanthone (
5
), leptosphaerin D (
6
), moniliphenone (
7
) and emodinbianthrone (
8
) have been isolated from a scale-up fermentation of the ascomycete fungus
Leptosphaeria
sp. Their structures were primarily elucidated by interpretation of NMR spectroscopic data. The absolute configuration of
1
was assigned using the modified Mosher method, whereas that of C-8a in
2
was determined via the CD data. Compound
6
showed modest cytotoxicity against a panel of three human tumor cell lines. |
| doi_str_mv | 10.1038/ja.2017.5 |
| format | Article |
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1
and
2
), two new xanthone derivatives, and six known compounds, leptosphaerin F (
3
), monodictysin B (
4
), norlichexanthone (
5
), leptosphaerin D (
6
), moniliphenone (
7
) and emodinbianthrone (
8
) have been isolated from a scale-up fermentation of the ascomycete fungus
Leptosphaeria
sp. Their structures were primarily elucidated by interpretation of NMR spectroscopic data. The absolute configuration of
1
was assigned using the modified Mosher method, whereas that of C-8a in
2
was determined via the CD data. Compound
6
showed modest cytotoxicity against a panel of three human tumor cell lines.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2017.5</identifier><identifier>PMID: 28196973</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/638/11/296 ; 639/638/403/936 ; Absolute configuration ; Antibiotics ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Ascomycota - metabolism ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Cell Line, Tumor ; Cytotoxicity ; Fermentation ; Fungi ; Humans ; Laboratories ; Leptosphaeria ; Life Sciences ; Magnetic Resonance Spectroscopy ; Medicinal Chemistry ; Microbiology ; Neoplasms - drug therapy ; Neoplasms - pathology ; NMR ; Nuclear magnetic resonance ; Organic Chemistry ; original-article ; Polyketides ; Polyketides - chemistry ; Polyketides - isolation & purification ; Polyketides - pharmacology ; Toxicity ; Tumor cell lines ; Tumors ; Xanthones - chemistry ; Xanthones - isolation & purification ; Xanthones - pharmacology</subject><ispartof>Journal of antibiotics, 2017-06, Vol.70 (6), p.743-746</ispartof><rights>Japan Antibiotics Research Association 2017</rights><rights>Copyright Nature Publishing Group Jun 2017</rights><rights>Japan Antibiotics Research Association 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-c6d5e1d58370b8509a7fe2e6fb52b98434bac9b09d90b57cce62b0160145867a3</citedby><cites>FETCH-LOGICAL-c435t-c6d5e1d58370b8509a7fe2e6fb52b98434bac9b09d90b57cce62b0160145867a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28196973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Jie</creatorcontrib><creatorcontrib>Wang, Renlei</creatorcontrib><creatorcontrib>Xu, Guohua</creatorcontrib><creatorcontrib>Ding, Zhengfeng</creatorcontrib><creatorcontrib>Zhu, Xueshen</creatorcontrib><creatorcontrib>Li, Erwei</creatorcontrib><creatorcontrib>Liu, Ling</creatorcontrib><title>Two new polyketides from the ascomycete fungus Leptosphaeria sp</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>Leptosphaerins H and I (
1
and
2
), two new xanthone derivatives, and six known compounds, leptosphaerin F (
3
), monodictysin B (
4
), norlichexanthone (
5
), leptosphaerin D (
6
), moniliphenone (
7
) and emodinbianthrone (
8
) have been isolated from a scale-up fermentation of the ascomycete fungus
Leptosphaeria
sp. Their structures were primarily elucidated by interpretation of NMR spectroscopic data. The absolute configuration of
1
was assigned using the modified Mosher method, whereas that of C-8a in
2
was determined via the CD data. Compound
6
showed modest cytotoxicity against a panel of three human tumor cell lines.</description><subject>639/638/11/296</subject><subject>639/638/403/936</subject><subject>Absolute configuration</subject><subject>Antibiotics</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Ascomycota - metabolism</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Cell Line, Tumor</subject><subject>Cytotoxicity</subject><subject>Fermentation</subject><subject>Fungi</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Leptosphaeria</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medicinal Chemistry</subject><subject>Microbiology</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - pathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organic Chemistry</subject><subject>original-article</subject><subject>Polyketides</subject><subject>Polyketides - chemistry</subject><subject>Polyketides - isolation & purification</subject><subject>Polyketides - pharmacology</subject><subject>Toxicity</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><subject>Xanthones - chemistry</subject><subject>Xanthones - isolation & purification</subject><subject>Xanthones - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90E1LHEEQBuAmGOKqOfgHZMCLCcxa1T39dQpBYhJY8KLnpqenRnezMz3pnkH23zuyRoKBnOpQD28VL2OnCEsEYS43fskB9VK-Yws0BkuslD1gCwCOpTEcDtlRzhsAoYU2H9ghN2iV1WLBvtw-xqKnx2KI290vGtcN5aJNsSvGByp8DrHbBRqpaKf-fsrFioYx5uHBU1r7Ig8n7H3rt5k-vsxjdnf97fbqR7m6-f7z6uuqDJWQYxlUIwkbaYSG2kiwXrfESbW15LU1lahqH2wNtrFQSx0CKV4DKsBKGqW9OGYX-9whxd8T5dF16xxou_U9xSk7NMpoQC71TM_f0E2cUj9_57hCKQUYYf6n0IJAnJtVs_q0VyHFnBO1bkjrzqedQ3DP3buNd8_dOznbs5fEqe6oeZV_yp7B5z3I86q_p_TXyX_SngC8a4p0</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Lin, Jie</creator><creator>Wang, Renlei</creator><creator>Xu, Guohua</creator><creator>Ding, Zhengfeng</creator><creator>Zhu, Xueshen</creator><creator>Li, Erwei</creator><creator>Liu, Ling</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Two new polyketides from the ascomycete fungus Leptosphaeria sp</title><author>Lin, Jie ; Wang, Renlei ; Xu, Guohua ; Ding, Zhengfeng ; Zhu, Xueshen ; Li, Erwei ; Liu, Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-c6d5e1d58370b8509a7fe2e6fb52b98434bac9b09d90b57cce62b0160145867a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>639/638/11/296</topic><topic>639/638/403/936</topic><topic>Absolute configuration</topic><topic>Antibiotics</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Ascomycota - metabolism</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Cell Line, Tumor</topic><topic>Cytotoxicity</topic><topic>Fermentation</topic><topic>Fungi</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Leptosphaeria</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medicinal Chemistry</topic><topic>Microbiology</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - pathology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organic Chemistry</topic><topic>original-article</topic><topic>Polyketides</topic><topic>Polyketides - chemistry</topic><topic>Polyketides - isolation & purification</topic><topic>Polyketides - pharmacology</topic><topic>Toxicity</topic><topic>Tumor cell lines</topic><topic>Tumors</topic><topic>Xanthones - chemistry</topic><topic>Xanthones - isolation & purification</topic><topic>Xanthones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Jie</creatorcontrib><creatorcontrib>Wang, Renlei</creatorcontrib><creatorcontrib>Xu, Guohua</creatorcontrib><creatorcontrib>Ding, Zhengfeng</creatorcontrib><creatorcontrib>Zhu, Xueshen</creatorcontrib><creatorcontrib>Li, Erwei</creatorcontrib><creatorcontrib>Liu, Ling</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Jie</au><au>Wang, Renlei</au><au>Xu, Guohua</au><au>Ding, Zhengfeng</au><au>Zhu, Xueshen</au><au>Li, Erwei</au><au>Liu, Ling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two new polyketides from the ascomycete fungus Leptosphaeria sp</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>70</volume><issue>6</issue><spage>743</spage><epage>746</epage><pages>743-746</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>Leptosphaerins H and I (
1
and
2
), two new xanthone derivatives, and six known compounds, leptosphaerin F (
3
), monodictysin B (
4
), norlichexanthone (
5
), leptosphaerin D (
6
), moniliphenone (
7
) and emodinbianthrone (
8
) have been isolated from a scale-up fermentation of the ascomycete fungus
Leptosphaeria
sp. Their structures were primarily elucidated by interpretation of NMR spectroscopic data. The absolute configuration of
1
was assigned using the modified Mosher method, whereas that of C-8a in
2
was determined via the CD data. Compound
6
showed modest cytotoxicity against a panel of three human tumor cell lines.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28196973</pmid><doi>10.1038/ja.2017.5</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of antibiotics, 2017-06, Vol.70 (6), p.743-746 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1868701257 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 639/638/11/296 639/638/403/936 Absolute configuration Antibiotics Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Ascomycota - metabolism Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cell Line, Tumor Cytotoxicity Fermentation Fungi Humans Laboratories Leptosphaeria Life Sciences Magnetic Resonance Spectroscopy Medicinal Chemistry Microbiology Neoplasms - drug therapy Neoplasms - pathology NMR Nuclear magnetic resonance Organic Chemistry original-article Polyketides Polyketides - chemistry Polyketides - isolation & purification Polyketides - pharmacology Toxicity Tumor cell lines Tumors Xanthones - chemistry Xanthones - isolation & purification Xanthones - pharmacology |
| title | Two new polyketides from the ascomycete fungus Leptosphaeria sp |
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