Two new polyketides from the ascomycete fungus Leptosphaeria sp
Leptosphaerins H and I ( 1 and 2 ), two new xanthone derivatives, and six known compounds, leptosphaerin F ( 3 ), monodictysin B ( 4 ), norlichexanthone ( 5 ), leptosphaerin D ( 6 ), moniliphenone ( 7 ) and emodinbianthrone ( 8 ) have been isolated from a scale-up fermentation of the ascomycete fung...
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| Veröffentlicht in: | Journal of antibiotics 2017-06, Vol.70 (6), p.743-746 |
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| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Leptosphaerins H and I (
1
and
2
), two new xanthone derivatives, and six known compounds, leptosphaerin F (
3
), monodictysin B (
4
), norlichexanthone (
5
), leptosphaerin D (
6
), moniliphenone (
7
) and emodinbianthrone (
8
) have been isolated from a scale-up fermentation of the ascomycete fungus
Leptosphaeria
sp. Their structures were primarily elucidated by interpretation of NMR spectroscopic data. The absolute configuration of
1
was assigned using the modified Mosher method, whereas that of C-8a in
2
was determined via the CD data. Compound
6
showed modest cytotoxicity against a panel of three human tumor cell lines. |
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| ISSN: | 0021-8820 1881-1469 |
| DOI: | 10.1038/ja.2017.5 |