Elevated expression of Erbin destabilizes ERα protein and promotes tumorigenesis in hepatocellular carcinoma

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Veröffentlicht in:	Journal of hepatology 2017-06, Vol.66 (6), p.1193-1204
Hauptverfasser:	Wu, Hua, Yao, Su, Zhang, Shen, Wang, Jing-Ru, Guo, Peng-Da, Li, Xiu-Ming, Gan, Wen-Juan, Mei, Lin, Gao, Tian-Ming, Li, Jian-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Antineoplastic Agents, Hormonal - therapeutic use Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor Cell Proliferation ERα signaling Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Female Gastroenterology and Hepatology Gene Silencing Hepatocellular carcinoma Humans Immunohistochemistry Liver Neoplasms - drug therapy Liver Neoplasms - etiology Liver Neoplasms - metabolism Liver Neoplasms, Experimental - etiology Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - metabolism Male Mice Mice, Inbred BALB C Mice, Nude Mouse model Prognosis Protein Stability Sex Factors Tamoxifen - therapeutic use Tamoxifen therapy Tumorigenesis Ubiquitin-Protein Ligases - metabolism Ubiquitination Up-Regulation
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