Novel roles for AhR and ARNT in the regulation of alcohol dehydrogenases in human hepatic cells

The mechanisms by which pollutants participate in the development of diverse pathologies are not completely understood. The pollutant 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) activates the AhR (aryl hydrocarbon receptor) signaling pathway. We previously showed that TCDD (25 nM, 30 h) decreased t...

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Veröffentlicht in:	Archives of toxicology 2017, Vol.91 (1), p.313-324
Hauptverfasser:	Attignon, Eléonore A., Leblanc, Alix F., Le-Grand, Béatrice, Duval, Caroline, Aggerbeck, Martine, Rouach, Hélène, Blanc, Etienne B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohol Dehydrogenase - antagonists & inhibitors Alcohol Dehydrogenase - chemistry Alcohol Dehydrogenase - genetics Alcohol Dehydrogenase - metabolism Animals Aryl Hydrocarbon Receptor Nuclear Translocator - agonists Aryl Hydrocarbon Receptor Nuclear Translocator - antagonists & inhibitors Aryl Hydrocarbon Receptor Nuclear Translocator - genetics Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism Basic Helix-Loop-Helix Transcription Factors - agonists Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biomedical and Life Sciences Biomedicine Carcinogens, Environmental - toxicity Cell Line, Tumor Cells Cells, Cultured Environmental Health Female Gene Expression Regulation, Enzymologic - drug effects Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Hepatology Humans Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - metabolism Ligands Male Metabolism Methylcholanthrene - toxicity Mice, Inbred C57BL Molecular Toxicology Occupational Medicine/Industrial Medicine Pathology Pesticides - toxicity Pharmacology/Toxicology Polychlorinated Biphenyls - toxicity Polychlorinated Dibenzodioxins - toxicity Random Allocation Receptors, Aryl Hydrocarbon - agonists Receptors, Aryl Hydrocarbon - antagonists & inhibitors Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism RNA Interference Signal Transduction - drug effects
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Zusammenfassung:	The mechanisms by which pollutants participate in the development of diverse pathologies are not completely understood. The pollutant 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) activates the AhR (aryl hydrocarbon receptor) signaling pathway. We previously showed that TCDD (25 nM, 30 h) decreased the expression of several alcohol metabolism enzymes (cytochrome P450 2E1, alcohol dehydrogenases ADH1, 4 and 6) in differentiated human hepatic cells (HepaRG). Here, we show that, as rapidly as 8 h after treatment (25 nM TCDD) ADH expression decreased 40 % ( p
ISSN:	0340-5761 1432-0738
DOI:	10.1007/s00204-016-1700-4