Evaluation of CC‐cytokine ligand 2 and complementary factor H Y402H polymorphisms and their interactional association with age‐related macular degeneration

Purpose To evaluate the association of CC‐cytokine ligand 2 CCL2–2518 (rs1024611) single nucleotide polymorphism, complement factor H (CFH Y402H) and their possible interaction in developing advanced age‐related macular degeneration (AMD). Methods In this case–control study, DNA samples from 266 patients with advanced AMD and 229 healthy controls were genotyped for CCL2 polymorphism and also 254 patients and 164 healthy controls were genotyped for CFH polymorphism. The possible associations of these polymorphisms with susceptibility to AMD independently and in different joint combinations were evaluated. Results The genotype frequency for CFH was found to be significantly different between AMD and normal controls (31.5% versus 20.7%, OR = 3.56, p