Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation

Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation

We investigated the uptake and pharmacokinetics of l-ergothioneine (ET), a dietary thione with free radical scavenging and cytoprotective capabilities, after oral administration to humans, and its effect on biomarkers of oxidative damage and inflammation. After oral administration, ET is avidly abso...

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Veröffentlicht in:Antioxidants & redox signaling 2017-02, Vol.26 (5), p.193-206
Hauptverfasser: Cheah, Irwin K, Tang, Richard M Y, Yew, Terry S Z, Lim, Keith H C, Halliwell, Barry
Format: Artikel
Sprache:eng
Schlagworte:
Allantoin
Allantoin - metabolism
Antioxidants
Antioxidants - administration & dosage
Antioxidants - chemistry
Antioxidants - pharmacokinetics
Betaine - analogs & derivatives
Betaine - metabolism
Biomarkers
Blood
C-reactive protein
C-Reactive Protein - metabolism
Carbonyls
Damage
Deoxyguanosine
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - metabolism
Deoxyribonucleic acid
Diet
DNA
DNA damage
Drug Monitoring
Ergothioneine - administration & dosage
Ergothioneine - chemistry
Ergothioneine - pharmacokinetics
Excretion
Free radicals
Healthy Volunteers
Histidine - analogs & derivatives
Histidine - metabolism
Humans
Inflammation
Inflammation - metabolism
Innovations
Lipid peroxidation
Lipids
Metabolism
Metabolites
Oral administration
Oxidation
Oxidative stress
Oxidative Stress - drug effects
Peroxidation
Pharmacokinetics
Pharmacology
Proteins
Scavenging
Uric acid
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Zusammenfassung:We investigated the uptake and pharmacokinetics of l-ergothioneine (ET), a dietary thione with free radical scavenging and cytoprotective capabilities, after oral administration to humans, and its effect on biomarkers of oxidative damage and inflammation. After oral administration, ET is avidly absorbed and retained by the body with significant elevations in plasma and whole blood concentrations, and relatively low urinary excretion (
ISSN:1523-0864
1557-7716
DOI:10.1089/ars.2016.6778