Cu( ii ) complex of a new isoindole derivative: structure, catecholase like activity, antimicrobial properties and bio-molecular interactions

An isoindole based Cu( ii ) complex, [ Cu(PICPH)Cl2 ], was synthesized in situ by reacting copper( ii ) chloride with a pyridine derived ligand, PICPH. The complex was characterized by spectroscopic techniques while its structure was confirmed by single crystal X-ray diffraction analysis. The complex has a trigonal bipyramid geometry containing both five- and seven-member chelate rings. It shows catecholase-like activity. Interaction of the complex with a bio-relevant antipyrine derivative ( ANNAP ) was studied using fluorescence spectroscopy. DFT studies unfold the energetics associated with PICPH, [ Cu(PICPH)Cl2 ] and the adduct between [ Cu(PICPH)Cl2 ] and ANNAP . Antimicrobial activities of the compounds were also studied.