Mimicking the Phenomenon of Ischemic Preconditioning by Actions on Cannabinoid Receptors: The Roles of Protein Kinase C and NO Synthase

Stimulation of CB1 receptors was found to mimic the phenomenon of preconditioning. As the cardioprotective effect of the cannabinoid HU-210 is seen in both in vivo experiments and in vitro studies, there are grounds for suggesting that the protective effects of HU-210 are mediated by activation of c...

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Veröffentlicht in:Neuroscience and behavioral physiology 2017, Vol.47 (1), p.25-32
Hauptverfasser: Lishmanov, Yu. B., Maslov, L. N., Krylatov, A. V., Khaliulin, I. G.
Format: Artikel
Sprache:eng
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Zusammenfassung:Stimulation of CB1 receptors was found to mimic the phenomenon of preconditioning. As the cardioprotective effect of the cannabinoid HU-210 is seen in both in vivo experiments and in vitro studies, there are grounds for suggesting that the protective effects of HU-210 are mediated by activation of cardiac CB1 receptors. The cardioprotective effect of the cannabinoid HU-210 was found to be linked with stimulation of protein kinase C, while NO synthase has no role in the protective action of stimulation of CB1 receptors.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-016-0362-2