Enzymatic antioxidant system of endotheliocytes

It is shown that endothelial cells from human umbilical vein have a reduced activity and gene expression of the “classic” antioxidant enzymes (Cu,Zn-superoxide dismutase, catalase, and Se-containing glutathione peroxidase). At the same time, a high expression level of peroxiredoxin genes was identif...

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Veröffentlicht in:	Doklady. Biochemistry and biophysics 2016-11, Vol.471 (1), p.410-412
Hauptverfasser:	Sharapov, M. G., Goncharov, R. G., Gordeeva, A. E., Novoselov, V. I., Antonova, O. A., Tikhaze, A. K., Lankin, V. Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Catalase - metabolism Cells, Cultured Endothelial Cells - enzymology Enzymes Erythrocytes - enzymology Gene Expression Glutathione Peroxidase - metabolism Humans Life Sciences Molecular Biology Oxidative stress Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Superoxide Dismutase-1 - metabolism Umbilical Veins - cytology Umbilical Veins - enzymology
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Zusammenfassung:	It is shown that endothelial cells from human umbilical vein have a reduced activity and gene expression of the “classic” antioxidant enzymes (Cu,Zn-superoxide dismutase, catalase, and Se-containing glutathione peroxidase). At the same time, a high expression level of peroxiredoxin genes was identified in the same endothelial cells, which obviously indicates the predominant involvement of these enzymes in protecting the endothelium from the damaging effect of free radical peroxidation.
ISSN:	1607-6729 1608-3091
DOI:	10.1134/S1607672916060090