Identification and characterization a novel HLA‐A allele, A02:355, by sequence‐based typing in a Chinese potential donor
Summary The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have sig...
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| Veröffentlicht in: | International journal of immunogenetics 2017-02, Vol.44 (1), p.35-37 |
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| container_title | International journal of immunogenetics |
| container_volume | 44 |
| creator | Nie, X‐M. Zhang, Y. Qiao, W‐B. Zhu, C‐F. Zhao, Y‐R. |
| description | Summary
The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects. |
| doi_str_mv | 10.1111/iji.12302 |
| format | Article |
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The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects.</description><identifier>ISSN: 1744-3121</identifier><identifier>EISSN: 1744-313X</identifier><identifier>DOI: 10.1111/iji.12302</identifier><identifier>PMID: 28044416</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Alleles ; Amino acid sequence ; Amino Acid Substitution ; Asian Continental Ancestry Group ; Base Sequence ; Exons ; Gene Expression ; Hematopoietic Stem Cell Transplantation ; Histocompatibility antigen HLA ; Histocompatibility Testing ; HLA-A2 Antigen - genetics ; HLA-A2 Antigen - immunology ; Humans ; Mutation ; Sequence Analysis, DNA ; Tissue Donors ; Tissue typing</subject><ispartof>International journal of immunogenetics, 2017-02, Vol.44 (1), p.35-37</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3862-76738bd77ed586ec2b4f2786039269056f6f9c325d50e769e36882ee0d5814c03</citedby><cites>FETCH-LOGICAL-c3862-76738bd77ed586ec2b4f2786039269056f6f9c325d50e769e36882ee0d5814c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiji.12302$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiji.12302$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28044416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nie, X‐M.</creatorcontrib><creatorcontrib>Zhang, Y.</creatorcontrib><creatorcontrib>Qiao, W‐B.</creatorcontrib><creatorcontrib>Zhu, C‐F.</creatorcontrib><creatorcontrib>Zhao, Y‐R.</creatorcontrib><title>Identification and characterization a novel HLA‐A allele, A02:355, by sequence‐based typing in a Chinese potential donor</title><title>International journal of immunogenetics</title><addtitle>Int J Immunogenet</addtitle><description>Summary
The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects.</description><subject>Alleles</subject><subject>Amino acid sequence</subject><subject>Amino Acid Substitution</subject><subject>Asian Continental Ancestry Group</subject><subject>Base Sequence</subject><subject>Exons</subject><subject>Gene Expression</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Histocompatibility antigen HLA</subject><subject>Histocompatibility Testing</subject><subject>HLA-A2 Antigen - genetics</subject><subject>HLA-A2 Antigen - immunology</subject><subject>Humans</subject><subject>Mutation</subject><subject>Sequence Analysis, DNA</subject><subject>Tissue Donors</subject><subject>Tissue typing</subject><issn>1744-3121</issn><issn>1744-313X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc-KFDEQh4Mo7rp68AUk4MWFnd3877S3YVjdkQEvCt5COl3tZsgkY9KjjHjwEXxGn8S0M-5BEKxLivDlqwo_hJ5ScklrXfm1v6SME3YPndJGiBmn_MP9u57RE_SolDUhXAlBHqITpokQgqpT9G3ZQxz94J0dfYrYxh67W5utGyH7r8dLHNNnCPhmNf_5_ccc2xAgwAWeE_aSS3mBuz0u8GkH0UEFOlugx-N-6-NH7Kfni1sfoQDepnGaZgPuU0z5MXow2FDgyfE8Q-9fXb9b3MxWb18vF_PVzHGt2KxRDddd3zTQS63AsU4MrNGK8Japlkg1qKF1nMleEmhUC1xpzQBIxalwhJ-hFwfvNqe6ZRnNxhcHIdgIaVcM1UpzRoSS_4FKSZRkbLI-_wtdp12O9SOGttWmKeETdX6gXE6lZBjMNvuNzXtDiZnSMzU98zu9yj47GnfdBvo78k9cFbg6AF98gP2_TWb5ZnlQ_gKAQKIr</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Nie, X‐M.</creator><creator>Zhang, Y.</creator><creator>Qiao, W‐B.</creator><creator>Zhu, C‐F.</creator><creator>Zhao, Y‐R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201702</creationdate><title>Identification and characterization a novel HLA‐A allele, A02:355, by sequence‐based typing in a Chinese potential donor</title><author>Nie, X‐M. ; Zhang, Y. ; Qiao, W‐B. ; Zhu, C‐F. ; Zhao, Y‐R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3862-76738bd77ed586ec2b4f2786039269056f6f9c325d50e769e36882ee0d5814c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alleles</topic><topic>Amino acid sequence</topic><topic>Amino Acid Substitution</topic><topic>Asian Continental Ancestry Group</topic><topic>Base Sequence</topic><topic>Exons</topic><topic>Gene Expression</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Histocompatibility antigen HLA</topic><topic>Histocompatibility Testing</topic><topic>HLA-A2 Antigen - genetics</topic><topic>HLA-A2 Antigen - immunology</topic><topic>Humans</topic><topic>Mutation</topic><topic>Sequence Analysis, DNA</topic><topic>Tissue Donors</topic><topic>Tissue typing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nie, X‐M.</creatorcontrib><creatorcontrib>Zhang, Y.</creatorcontrib><creatorcontrib>Qiao, W‐B.</creatorcontrib><creatorcontrib>Zhu, C‐F.</creatorcontrib><creatorcontrib>Zhao, Y‐R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of immunogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nie, X‐M.</au><au>Zhang, Y.</au><au>Qiao, W‐B.</au><au>Zhu, C‐F.</au><au>Zhao, Y‐R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification and characterization a novel HLA‐A allele, A02:355, by sequence‐based typing in a Chinese potential donor</atitle><jtitle>International journal of immunogenetics</jtitle><addtitle>Int J Immunogenet</addtitle><date>2017-02</date><risdate>2017</risdate><volume>44</volume><issue>1</issue><spage>35</spage><epage>37</epage><pages>35-37</pages><issn>1744-3121</issn><eissn>1744-313X</eissn><abstract>Summary
The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28044416</pmid><doi>10.1111/iji.12302</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1744-3121 |
| ispartof | International journal of immunogenetics, 2017-02, Vol.44 (1), p.35-37 |
| issn | 1744-3121 1744-313X |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alleles Amino acid sequence Amino Acid Substitution Asian Continental Ancestry Group Base Sequence Exons Gene Expression Hematopoietic Stem Cell Transplantation Histocompatibility antigen HLA Histocompatibility Testing HLA-A2 Antigen - genetics HLA-A2 Antigen - immunology Humans Mutation Sequence Analysis, DNA Tissue Donors Tissue typing |
| title | Identification and characterization a novel HLA‐A allele, A02:355, by sequence‐based typing in a Chinese potential donor |
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