Identification and characterization a novel HLA‐A allele, A02:355, by sequence‐based typing in a Chinese potential donor

Identification and characterization a novel HLA‐A allele, A02:355, by sequence‐based typing in a Chinese potential donor

Summary The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have sig...

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Veröffentlicht in:International journal of immunogenetics 2017-02, Vol.44 (1), p.35-37
Hauptverfasser: Nie, X‐M., Zhang, Y., Qiao, W‐B., Zhu, C‐F., Zhao, Y‐R.
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Amino acid sequence
Amino Acid Substitution
Asian Continental Ancestry Group
Base Sequence
Exons
Gene Expression
Hematopoietic Stem Cell Transplantation
Histocompatibility antigen HLA
Histocompatibility Testing
HLA-A2 Antigen - genetics
HLA-A2 Antigen - immunology
Humans
Mutation
Sequence Analysis, DNA
Tissue Donors
Tissue typing
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Zusammenfassung:Summary The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects.
ISSN:1744-3121
1744-313X
DOI:10.1111/iji.12302