Differences in the risk of fatty liver for onset of impaired fasting glucose according to baseline plasma glucose levels

Background It remains unclear whether fatty liver is a risk factor for the onset of abnormal glucose tolerance in any patient. The objective of this study was to clarify the relationship between fatty liver and the onset of impaired fasting glucose according to baseline fasting plasma glucose (FPG) levels. Methods This community-based longitudinal cohort study included 7,905 adults (3,863 men, 4,042 women; age range, 18–80 years) who had at least two annual checkups between 2003 and 2013. Those with FPG levels ≥110 mg/dl, taking anti-diabetic agents, and/or testing positive for hepatitis B surface antigen or anti-hepatitis C virus antibody were excluded, leaving 7,203 participants eligible for inclusion. All participants were divided into quartiles derived from their FPG levels at baseline. FPG ≥110 mg/dl during the observation period was defined as onset of IFG. Results Onset of IFG was found in 7.7 % of men and 2.1 % of women ( p