The ratio of cancer cells to stroma after induction therapy in the treatment of non-small cell lung cancer

Purpose Induction therapy induces degenerative changes of various degrees in both cancerous and non-cancerous cells of non-small cell lung cancer (NSCLC). The effect of induction therapy on histological characteristics, in particular the ratio of residual cancer cells to non-cancerous components, is...

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Veröffentlicht in:Journal of cancer research and clinical oncology 2017-02, Vol.143 (2), p.215-223
Hauptverfasser: Goto, Masaki, Naito, Masahito, Saruwatari, Koichi, Hisakane, Kakeru, Kojima, Motohiro, Fujii, Satoshi, Kuwata, Takeshi, Ochiai, Atsushi, Nomura, Shogo, Aokage, Keiju, Hishida, Tomoyuki, Yoshida, Junji, Yokoi, Kohei, Tsuboi, Masahiro, Ishii, Genichiro
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Sprache:eng
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Zusammenfassung:Purpose Induction therapy induces degenerative changes of various degrees in both cancerous and non-cancerous cells of non-small cell lung cancer (NSCLC). The effect of induction therapy on histological characteristics, in particular the ratio of residual cancer cells to non-cancerous components, is unknown. Methods Seventy-four NSCLC patients treated with induction therapy followed by surgery were enrolled. Residual cancer cells were identified using anti-pan-cytokeratin antibody (AE1/AE3). We analyzed and quantified the following three factors via digital image analysis; (1) the tumor area containing cancer cells and non-cancerous components (TA), (2) the total area of AE1/AE3 positive cancer cells (TACC), (3) the percentage of TACC to TA (%TACC). These factors were also analyzed in a matched control group (surgery alone, n  = 80). Results The median TACC of the induction therapy group was significantly lower than that of the control group ( p  
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-016-2271-8