Efficacy of a topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel (Broadline®) against naturally acquired infections with cestodes of the genus Joyeuxiella in cats

Cats are host to dipylidiid cestodes of the genera Diplopylidium , Dipylidium and Joyeuxiella . Broadline ® , a topical broad-spectrum combination parasiticide containing fipronil (8.3 % w / v ), (S)-methoprene (10 % w / v ), eprinomectin (0.4 % w / v ) and the cestocide praziquantel (8.3 % w / v ), has previously been shown to be efficacious against Dipylidium caninum and Diplopylidium spp. in cats. To evaluate its efficacy against Joyeuxiella species, a blinded clinical efficacy study was conducted according to GCP. All cats had evidence for naturally acquired dipylidiid cestode infection as confirmed by pre-treatment examination. Cats were allocated randomly to two groups of 13 cats each based on bodyweight: Control (untreated) and Broadline ® at 0.12 mL/kg bodyweight administered once topically. Based on the comparison of helminth counts in the treated and untreated cats seven days post treatment, Broadline ® demonstrated >99 % efficacy ( p