Exploration of bladder cancer molecular mechanisms based on miRNA-mRNA regulatory network

To explore the complex molecular mechanisms of bladder cancer, mRNA and miRNA expression profiles were combined for systematic analyses. A total of 18 common differentially expressed genes (DEGs) were identified from two mRNA expression datasets which consisted of 206 tumor and 74 normal tissues. Th...

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Veröffentlicht in:	Oncology reports 2017-03, Vol.37 (3), p.1461-1468
Hauptverfasser:	Li, Wenfeng, Liu, Jia, Zou, Di, Cai, Xiaye, Wang, Jingying, Wang, Jinmeng, Zhu, Li, Zhao, Liang, Ou, Rongying, Xu, Yunsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Dehydrogenase - genetics Analysis Angiogenesis Bladder cancer Care and treatment Cell cycle Datasets Development and progression Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genetic aspects Health aspects Humans Kinases Messenger RNA Metastasis MicroRNA MicroRNAs - genetics Ontology Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Studies Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology
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Zusammenfassung:	To explore the complex molecular mechanisms of bladder cancer, mRNA and miRNA expression profiles were combined for systematic analyses. A total of 18 common differentially expressed genes (DEGs) were identified from two mRNA expression datasets which consisted of 206 tumor and 74 normal tissues. Then, survival analysis based on the SurvExpress database showed that the common DEGs were able to significantly differentiate low- and high-risk groups in 4 public bladder cancer datasets (p
ISSN:	1021-335X 1791-2431
DOI:	10.3892/or.2017.5433