Expression of oncogenic miR-17-92 and tumor suppressive miR-143-145 clusters in basal cell carcinoma and cutaneous squamous cell carcinoma

Highlights • microRNAs can have an oncogenic or tumor-supressive effect. • miR-17-92 cluster (Oncomir-1) is oncogenic and miR-143-145 tumor supressive. • miR-17-92 and miR-143-5p were highly significant increased in cSCC. • miR-145-5p was significantly decreased in BCC. • miR-17-92 and miR-143-145 s...

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Veröffentlicht in:	Journal of dermatological science 2017-05, Vol.86 (2), p.142-148
Hauptverfasser:	Sand, Michael, Hessam, Schapoor, Amur, Susanne, Skrygan, Marina, Bromba, Michael, Stockfleth, Eggert, Gambichler, Thilo, Bechara, Falk G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Basal cell carcinoma Carcinogenesis Carcinoma, Basal Cell - genetics Carcinoma, Squamous Cell - genetics Cell Line, Tumor Dermatology Female Gene Expression Regulation, Neoplastic Humans Male MicroRNAs - genetics Middle Aged miR-143-145 miR-17-92 Non-coding RNAs Oncomir-1 Real-Time Polymerase Chain Reaction Skin Neoplasms - genetics Squamous cell carcinoma
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Beschreibung
Zusammenfassung:	Highlights • microRNAs can have an oncogenic or tumor-supressive effect. • miR-17-92 cluster (Oncomir-1) is oncogenic and miR-143-145 tumor supressive. • miR-17-92 and miR-143-5p were highly significant increased in cSCC. • miR-145-5p was significantly decreased in BCC. • miR-17-92 and miR-143-145 show dysregulation in epidermal skin cancer.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2017.01.012