Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction　― Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy

Background:Acute kidney injury (AKI) is associated with poor outcome after acute myocardial infarction (AMI), but whether hemodynamic status at presentation influences this prognostic significance is unknown.Methods and Results:A total of 2,798 AMI patients admitted within 48 h after symptom onset and who underwent urgent coronary angiography were enrolled in the present study. AKI was defined as an increase in serum creatinine ≥0.3 mg/dL or ≥50% within 48 h during hospitalization. Patients were classified into 3 groups according to Killip class on admission: Killip 1, n=2,164; Killip 2–3, n=366; and Killip 4, n=268. AKI occurred more frequently with increasing Killip class (Killip 1, 2–3, and 4: 6.3%, 15.3%, and 31.3%, respectively; P