Molecular characterization and functional analysis of pituitary GnRH receptor in a commercial scombroid fish, chub mackerel ( Scomber japonicus )

Highlights • The present GnRH receptor can be activated by different GnRH peptides. • All three GnRH ligands stimulate LH release in vitro. • mRNA expression of cmgnrhr1 is mainly detected in the pituitary. • The cmgnrhr1 pituitary levels increases as it undergoes gonadal development. • cmGnRHR1 is...

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Veröffentlicht in:	General and comparative endocrinology 2017-06, Vol.247, p.143-151
Hauptverfasser:	Lumayno, Sanny David Pacheco, Ohga, Hirofumi, Selvaraj, Sethu, Nyuji, Mitsuo, Yamaguchi, Akihiko, Matsuyama, Michiya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Chub mackerel DNA, Complementary - genetics Endocrinology & Metabolism Female Gonadotropin releasing hormone Gonadotropin releasing hormone receptor Ligands Luteinizing hormone Male Perciformes - metabolism Phylogeny Pituitary Gland - metabolism Puberty Receptors, LHRH - genetics Receptors, LHRH - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Analysis, DNA Tissue Distribution
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Zusammenfassung:	Highlights • The present GnRH receptor can be activated by different GnRH peptides. • All three GnRH ligands stimulate LH release in vitro. • mRNA expression of cmgnrhr1 is mainly detected in the pituitary. • The cmgnrhr1 pituitary levels increases as it undergoes gonadal development. • cmGnRHR1 is functionally important in chub mackerel puberty.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2017.01.027