Influence of different proton pump inhibitors on the pharmacokinetics of voriconazole

Influence of different proton pump inhibitors on the pharmacokinetics of voriconazole

Highlights • Study comparing the effect of proton pump inhibitors (PPIs) on voriconazole pharmacokinetics. • Physiologically based pharmacokinetic (PBPK) model was used to predict pharmacokinetic profiles. • PBPK model used to assess the drug–drug interaction potential of voriconazole with PPIs. • O...

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Veröffentlicht in:International journal of antimicrobial agents 2017-04, Vol.49 (4), p.403-409
Hauptverfasser: Qi, Fang, Zhu, Liqin, Li, Na, Ge, Tingyue, Xu, Gaoqi, Liao, Shasha
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antifungal Agents - pharmacokinetics
Drug Interactions
Drug–drug interactions
Humans
Infectious Disease
Male
Models, Statistical
PBPK model
Plasma - chemistry
PPI
Proton pump inhibitors
Proton Pump Inhibitors - pharmacokinetics
Time Factors
Voriconazole
Voriconazole - pharmacokinetics
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Beschreibung
Zusammenfassung:Highlights • Study comparing the effect of proton pump inhibitors (PPIs) on voriconazole pharmacokinetics. • Physiologically based pharmacokinetic (PBPK) model was used to predict pharmacokinetic profiles. • PBPK model used to assess the drug–drug interaction potential of voriconazole with PPIs. • Omeprazole was the most potent CYP2C19 inhibitor tested; rabeprazole had no influence on voriconazole. • Dosage adjustment of voriconazole is unnecessary regardless of which PPI was co-administered.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2016.11.025