The association of neonatal morbidity with long‐term neurological outcome in infants who were growth restricted and preterm at birth: secondary analyses from TRUFFLE (Trial of Randomized Umbilical and Fetal Flow in Europe)

Objective To study the relationship between neonatal morbidity (NNM) and two‐year neurodevelopmental impairment (NDI) in surviving children after early fetal growth restriction (FGR). Design Secondary analysis of a European randomised trial (TRUFFLE) of delivery for very preterm fetuses dependent on venous Doppler or cardiotocographic criteria. Setting Tertiary perinatal centres, participants in TRUFFLE. Population 402 surviving children after early FGR. Methods Prospective data were collection from the recognition of FGR until the corrected age of two years. We studied the association between NNM and NDI, retaining trial allocation in all statistical models. NNM included any of bronchopulmonary dysplasia, brain injury, sepsis or necrotising enterocolitis. NDI was a composite of Bayley cognitive score