Differential reactive oxygen species production of neutrophils and their oxidative damage in patients with active and inactive Systemic Lupus erythematosus

Highlights • High production rate of ROS in SLE patients derived PMN after fMLP and TPA stimulation. • Biphasic response profile in SLE patients PMN after fMLP stimulation. • Difference in PMN oxidative burst between active and remission phase. • Lipid peroxidation and protein oxidation in SLE PMN l...

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Veröffentlicht in:	Immunology letters 2017-04, Vol.184, p.1-6
Hauptverfasser:	Elloumi, Nesrine, Mansour, Riadh Ben, Marzouk, Sameh, Mseddi, Malek, Fakhfakh, Raouia, Gargouri, Bochra, Masmoudi, Hatem, Lassoued, Saloua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Biomarkers Case-Control Studies Disease Progression Female fMLP/TPA Humans Lipid Peroxidation Low density granulocytes (LDG) Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Male Malondialdehyd(MDA) Middle Aged Neutrophils - immunology Neutrophils - metabolism Neutrophils activation Oxidation-Reduction Reactive Oxygen Species - metabolism Reactive oxygen species production Systemic lupus erythematosus Young Adult
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Zusammenfassung:	Highlights • High production rate of ROS in SLE patients derived PMN after fMLP and TPA stimulation. • Biphasic response profile in SLE patients PMN after fMLP stimulation. • Difference in PMN oxidative burst between active and remission phase. • Lipid peroxidation and protein oxidation in SLE PMN lysates
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2017.01.018