Bumetanide Reduce the Seizure Susceptibility Induced by Pentylenetetrazol via Inhibition of Aberrant Hippocampal Neurogenesis in Neonatal Rats after Hypoxia-Ischemia
Highlights • The expression of NKCC1 is increased after hypoxia-ischemia • Bumetanide restores the ectopia of granule cells in hippocampus • Bumetanide reduces the PTZ induced seizure susceptibility in hypoxia-ischemia neonatal rats • Bumetanide restores the aberrant neurogenesis associated hippocam...
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| Veröffentlicht in: | Brain research bulletin 2017-04, Vol.130, p.188-199 |
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| container_title | Brain research bulletin |
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| creator | Hu, Jiang-jian Yang, Xing-liang Luo, Wen-di Han, Song Yin, Jun Liu, Wan-hong He, Xiao-Hua Peng, Bi-Wen |
| description | Highlights • The expression of NKCC1 is increased after hypoxia-ischemia • Bumetanide restores the ectopia of granule cells in hippocampus • Bumetanide reduces the PTZ induced seizure susceptibility in hypoxia-ischemia neonatal rats • Bumetanide restores the aberrant neurogenesis associated hippocampal memory and recognition |
| doi_str_mv | 10.1016/j.brainresbull.2017.01.022 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-3c6cd3bcf283a33ac15819408aedc70b5d1c437dba2a4f82223ce30cea1a283d3</citedby><cites>FETCH-LOGICAL-c435t-3c6cd3bcf283a33ac15819408aedc70b5d1c437dba2a4f82223ce30cea1a283d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainresbull.2017.01.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28161194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Jiang-jian</creatorcontrib><creatorcontrib>Yang, Xing-liang</creatorcontrib><creatorcontrib>Luo, Wen-di</creatorcontrib><creatorcontrib>Han, Song</creatorcontrib><creatorcontrib>Yin, Jun</creatorcontrib><creatorcontrib>Liu, Wan-hong</creatorcontrib><creatorcontrib>He, Xiao-Hua</creatorcontrib><creatorcontrib>Peng, Bi-Wen</creatorcontrib><title>Bumetanide Reduce the Seizure Susceptibility Induced by Pentylenetetrazol via Inhibition of Aberrant Hippocampal Neurogenesis in Neonatal Rats after Hypoxia-Ischemia</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Highlights • The expression of NKCC1 is increased after hypoxia-ischemia • Bumetanide restores the ectopia of granule cells in hippocampus • Bumetanide reduces the PTZ induced seizure susceptibility in hypoxia-ischemia neonatal rats • Bumetanide restores the aberrant neurogenesis associated hippocampal memory and recognition</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Anticonvulsants - administration & dosage</subject><subject>Bumetanide</subject><subject>Bumetanide - administration & dosage</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation</subject><subject>Cognitive decline</subject><subject>Electroencephalography</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - physiopathology</subject><subject>Hypoxia-ischemia brain damage</subject><subject>Hypoxia-Ischemia, Brain - complications</subject><subject>Memory - drug effects</subject><subject>Neurogenesis</subject><subject>Neurogenesis - drug effects</subject><subject>Neurology</subject><subject>NKCC1</subject><subject>Pentylenetetrazole - administration & dosage</subject><subject>Rats, Sprague-Dawley</subject><subject>Seizures - chemically induced</subject><subject>Seizures - complications</subject><subject>Seizures - metabolism</subject><subject>Seizures - physiopathology</subject><subject>Solute Carrier Family 12, Member 2 - metabolism</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkstuFDEQRVsIRIbALyCLFZtu_Jh-hAVSCI8ZKQKUwNqqdlczHtx240dE53_4TzyagBArViXL51ap7q2ieMZoxShrXuyr3oO2HkOfjKk4ZW1FWUU5v1esWNeKkrfr9n6xoqJh5RkX9KR4FMKeUtp0dfOwOOEdaxg7W6-Kn6_ThBGsHpBc4ZAUkrhDco36NvlcU1A4R91ro-NCtvZADKRfyCe0cTFoMWL0cOsMudGQgV1mo3aWuJGc9-g92Eg2ep6dgmkGQz5g8u5rFgYdiLb57SzE_HEFMRAYI3qyWWb3Q0O5DWqHk4bHxYMRTMAnd_W0-PLu7eeLTXn58f324vyyVGtRx1KoRg2iVyPvBAgBitVd3pJ2gINqaV8PLIPt0AOH9dhxzoVCQRUCgywZxGnx_Nh39u57whDlpLMBxoBFl4JkXVPXrM3uZfTlEVXeheBxlLPXE_hFMioPMcm9_DsmeYhJUiZzTFn89G5O6icc_kh_55KBN0cA87Y3Gr0MSqPN3muPKsrB6f-b8-qfNspoqxWYb7hg2LvkbfZTMhm4pPL6cDCHe8n7UdG1XPwCx-3EYw</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Hu, Jiang-jian</creator><creator>Yang, Xing-liang</creator><creator>Luo, Wen-di</creator><creator>Han, Song</creator><creator>Yin, Jun</creator><creator>Liu, Wan-hong</creator><creator>He, Xiao-Hua</creator><creator>Peng, Bi-Wen</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Bumetanide Reduce the Seizure Susceptibility Induced by Pentylenetetrazol via Inhibition of Aberrant Hippocampal Neurogenesis in Neonatal Rats after Hypoxia-Ischemia</title><author>Hu, Jiang-jian ; 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| ispartof | Brain research bulletin, 2017-04, Vol.130, p.188-199 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Animals, Newborn Anticonvulsants - administration & dosage Bumetanide Bumetanide - administration & dosage Cell Movement - drug effects Cell Proliferation Cognitive decline Electroencephalography Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology Hypoxia-ischemia brain damage Hypoxia-Ischemia, Brain - complications Memory - drug effects Neurogenesis Neurogenesis - drug effects Neurology NKCC1 Pentylenetetrazole - administration & dosage Rats, Sprague-Dawley Seizures - chemically induced Seizures - complications Seizures - metabolism Seizures - physiopathology Solute Carrier Family 12, Member 2 - metabolism |
| title | Bumetanide Reduce the Seizure Susceptibility Induced by Pentylenetetrazol via Inhibition of Aberrant Hippocampal Neurogenesis in Neonatal Rats after Hypoxia-Ischemia |
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