Bumetanide Reduce the Seizure Susceptibility Induced by Pentylenetetrazol via Inhibition of Aberrant Hippocampal Neurogenesis in Neonatal Rats after Hypoxia-Ischemia

Highlights • The expression of NKCC1 is increased after hypoxia-ischemia • Bumetanide restores the ectopia of granule cells in hippocampus • Bumetanide reduces the PTZ induced seizure susceptibility in hypoxia-ischemia neonatal rats • Bumetanide restores the aberrant neurogenesis associated hippocam...

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Veröffentlicht in:	Brain research bulletin 2017-04, Vol.130, p.188-199
Hauptverfasser:	Hu, Jiang-jian, Yang, Xing-liang, Luo, Wen-di, Han, Song, Yin, Jun, Liu, Wan-hong, He, Xiao-Hua, Peng, Bi-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Anticonvulsants - administration & dosage Bumetanide Bumetanide - administration & dosage Cell Movement - drug effects Cell Proliferation Cognitive decline Electroencephalography Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology Hypoxia-ischemia brain damage Hypoxia-Ischemia, Brain - complications Memory - drug effects Neurogenesis Neurogenesis - drug effects Neurology NKCC1 Pentylenetetrazole - administration & dosage Rats, Sprague-Dawley Seizures - chemically induced Seizures - complications Seizures - metabolism Seizures - physiopathology Solute Carrier Family 12, Member 2 - metabolism
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Zusammenfassung:	Highlights • The expression of NKCC1 is increased after hypoxia-ischemia • Bumetanide restores the ectopia of granule cells in hippocampus • Bumetanide reduces the PTZ induced seizure susceptibility in hypoxia-ischemia neonatal rats • Bumetanide restores the aberrant neurogenesis associated hippocampal memory and recognition
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2017.01.022