Reduction of Anthelmintic Drug (Methyl [1]carbamate-albendazole) on Gold Electrodes in Aprotic Solvent: Analysis of Chromatographic Reduction Products

Albendazole (ABZ) is a widely used anthelmintic drug for the treatment of parasitic worms and other diseases. The bulk electrolysis reduction reaction of albendazole (ABZ) was carried out in ammonium bromide‐acetonitrile solution under stirring conditions. The reduction of albendazole at gold electrode gave three non‐reversible waves. The average value of the electron transfer coefficient (nα) was found to be 0.505. The measured diffusion coefficient (D) had a value of 0.143×10−8 cm2 s−1. The bulk electrochemical reduction of ABZ products were characterized using liquid chromatography‐mass spectroscopy. Three cyclic voltammetry reduction waves were observed using a gold electrode and three chromatographic peaks were observed using liquid chromatography‐ Mass spectrometry. The observed results suggested that the second and third reduction steps occurred at the sulfur functional group of albendazole.