Supramolecular cyclodextrin nanocarriers for chemo- and gene therapy towards the effective treatment of drug resistant cancers

Supramolecular cyclodextrin nanocarriers for chemo- and gene therapy towards the effective treatment of drug resistant cancers

A tumor active targeting β-cyclodextrin based nanocarrier β-NC-OEI-SS-FA was designed by the modification of star shaped cationic derivatives β-NC-OEI with folic acid through a disulfide bond, to co-deliver chemotherapeutic paclitaxel and the Nur77 gene for overcoming Bcl-2 mediated non-pump resista...

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Veröffentlicht in:Nanoscale 2016-12, Vol.8 (45), p.18876-18881
Hauptverfasser: Chen, Xiaohong, Qiu, Ying-Kun, Owh, Cally, Loh, Xian Jun, Wu, Yun-Long
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Cationic
Derivatives
Drugs
Folic acid
Genes
Nanostructure
Strategy
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Zusammenfassung:A tumor active targeting β-cyclodextrin based nanocarrier β-NC-OEI-SS-FA was designed by the modification of star shaped cationic derivatives β-NC-OEI with folic acid through a disulfide bond, to co-deliver chemotherapeutic paclitaxel and the Nur77 gene for overcoming Bcl-2 mediated non-pump resistance by an "enemy to friend" strategy for potential drug resistant cancer therapy.
ISSN:2040-3364
2040-3372
DOI:10.1039/c6nr08055c