Densities of L-Glutamic Acid HCl Drug in Aqueous NaCl and KCl Solutions at Different Temperatures
Densities ( ρ ) of (0.01 to 0.07) mol · kg - 1 L-Glutamic acid HCl (L-HCl) drug in water, and in aqueous NaCl and KCl (0.5 and 1.0) mol · kg - 1 solutions have been reported as a function of temperature at T = ( 298.15 , 303.15 , 308.15 , and 313.15) K and atmospheric pressure. The accurate density...
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Veröffentlicht in: | International journal of thermophysics 2016-04, Vol.37 (4), p.1-10, Article 43 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
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Zusammenfassung: | Densities
(
ρ
)
of (0.01 to 0.07)
mol
·
kg
-
1
L-Glutamic acid HCl (L-HCl) drug in water, and in aqueous NaCl and KCl (0.5 and 1.0)
mol
·
kg
-
1
solutions have been reported as a function of temperature at
T
=
(
298.15
,
303.15
,
308.15
, and 313.15) K and atmospheric pressure. The accurate density
(
ρ
)
values are used to estimate the various parameters such as the apparent molar volume
(
V
2
,
ϕ
)
, the partial molar volume
(
V
2
∞
)
, the isobaric thermal expansion coefficient
(
α
2
)
, the partial molar expansion
(
E
2
∞
)
, and Hepler’s constant
(
∂
2
V
2
∞
/
∂
T
2
)
P
. The Cosphere overlap model is used to understand the solute–solvent interactions in a ternary mixture (L-HCl drug + NaCl or KCl + water). Hepler’s constant
(
∂
2
V
2
∞
/
∂
T
2
)
P
is utilized to interpret the structure-making or -breaking ability of L-HCl drug in aqueous NaCl and KCl solutions, and the results are inferred that L-HCl drug acts as a structure maker, i.e., kosmotrope in aqueous NaCl solutions and performs as a structure breaker, i.e., chaotrope in aqueous KCl solutions. |
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ISSN: | 0195-928X 1572-9567 |
DOI: | 10.1007/s10765-015-2009-x |