Densities of L-Glutamic Acid HCl Drug in Aqueous NaCl and KCl Solutions at Different Temperatures

Densities ( ρ ) of (0.01 to 0.07) mol · kg - 1 L-Glutamic acid HCl (L-HCl) drug in water, and in aqueous NaCl and KCl (0.5 and 1.0) mol · kg - 1 solutions have been reported as a function of temperature at T = ( 298.15 , 303.15 , 308.15 , and 313.15) K and atmospheric pressure. The accurate density...

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Veröffentlicht in:International journal of thermophysics 2016-04, Vol.37 (4), p.1-10, Article 43
Hauptverfasser: Ryshetti, Suresh, Raghuram, Noothi, Rani, Emmadi Jayanthi, Tangeda, Savitha Jyostna
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Sprache:eng
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Zusammenfassung:Densities ( ρ ) of (0.01 to 0.07) mol · kg - 1 L-Glutamic acid HCl (L-HCl) drug in water, and in aqueous NaCl and KCl (0.5 and 1.0) mol · kg - 1 solutions have been reported as a function of temperature at T = ( 298.15 , 303.15 , 308.15 , and 313.15) K and atmospheric pressure. The accurate density ( ρ ) values are used to estimate the various parameters such as the apparent molar volume ( V 2 , ϕ ) , the partial molar volume ( V 2 ∞ ) , the isobaric thermal expansion coefficient ( α 2 ) , the partial molar expansion ( E 2 ∞ ) , and Hepler’s constant ( ∂ 2 V 2 ∞ / ∂ T 2 ) P . The Cosphere overlap model is used to understand the solute–solvent interactions in a ternary mixture (L-HCl drug + NaCl or KCl + water). Hepler’s constant ( ∂ 2 V 2 ∞ / ∂ T 2 ) P is utilized to interpret the structure-making or -breaking ability of L-HCl drug in aqueous NaCl and KCl solutions, and the results are inferred that L-HCl drug acts as a structure maker, i.e., kosmotrope in aqueous NaCl solutions and performs as a structure breaker, i.e., chaotrope in aqueous KCl solutions.
ISSN:0195-928X
1572-9567
DOI:10.1007/s10765-015-2009-x