Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa

Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa

We explore the chemical space of Pseudomonas quinolone signal analogs as privileged structures and report the discovery of a thioquinolone as a potent inhibitor of the important virulence factor elastase of the human pathogen Pseudomonas aeruginosa. We provide evidence that the derivative binds to t...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (92), p.13440-13443
Hauptverfasser: Szamosvári, Dávid, Reichle, Valentin F, Jureschi, Monica, Böttcher, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
Derivatives
Elastase
Pathogens
Pseudomonas
Pseudomonas aeruginosa
Virulence
Zinc
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Zusammenfassung:We explore the chemical space of Pseudomonas quinolone signal analogs as privileged structures and report the discovery of a thioquinolone as a potent inhibitor of the important virulence factor elastase of the human pathogen Pseudomonas aeruginosa. We provide evidence that the derivative binds to the active site zinc of elastase and additionally acts as a fluorescent zinc sensor.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc06295d