Apparent Carbon Monoxide Insertion via Double Isocyanide Incorporation during Palladium-Catalyzed Construction of Indoloquinoline Ring in a Single Pot: Synthesis of New Cytotoxic Agents

Apparent Carbon Monoxide Insertion via Double Isocyanide Incorporation during Palladium-Catalyzed Construction of Indoloquinoline Ring in a Single Pot: Synthesis of New Cytotoxic Agents

The formation of an amide bond via incorporation of two isocyanide units during a palladium‐catalyzed construction of the indoloquinoline ring afforded N‐substituted 6H‐indolo[2,3‐b]quinoline‐11‐carboxamides as new cytotoxic agents. The solvent and base play a key role in the selective and unprecede...

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Veröffentlicht in:Advanced synthesis & catalysis 2016-11, Vol.358 (21), p.3387-3393
Hauptverfasser: Nallapati, Suresh Babu, Prasad, Bagineni, Sreenivas, B. Yogi, Sunke, Rajnikanth, Poornachandra, Y., Kumar, C. Ganesh, Sridhar, B., Shivashankar, S., Mukkanti, K., Pal, Manojit
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Bonding agents
Carbon monoxide
cytotoxic agents
Formations
indoloquinolines
Insertion
isocyanides
Palladium
Solvents
Synthesis
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Zusammenfassung:The formation of an amide bond via incorporation of two isocyanide units during a palladium‐catalyzed construction of the indoloquinoline ring afforded N‐substituted 6H‐indolo[2,3‐b]quinoline‐11‐carboxamides as new cytotoxic agents. The solvent and base play a key role in the selective and unprecedented synthesis of this class of amides.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600599