Mechanical properties and composition of carotid and femoral atherosclerotic plaques: A comparative study

Abstract This study compares the mechanical properties of excised carotid and femoral human plaques and also develops a predictor of these properties based on plaque composition. Circumferential planar tension tests were performed on 24 carotid and 16 femoral plaque samples. Composition was characte...

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Veröffentlicht in:	Journal of biomechanics 2016-11, Vol.49 (15), p.3697-3704
Hauptverfasser:	Cunnane, Eoghan M, Mulvihill, John J.E, Barrett, Hilary E, Hennessy, Mairead M, Kavanagh, Eamon G, Walsh, Michael T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aids Atherosclerotic plaque Carotid Carotid Arteries - pathology Carotid Arteries - physiology Clinical outcomes Composition Correlation Endovascular treatment Failure Female Femoral Femoral Artery - pathology Femoral Artery - physiology Fourier transforms FTIR Humans Lipids Male Mechanical properties Middle Aged Physical Medicine and Rehabilitation Plaque, Atherosclerotic - pathology Plaque, Atherosclerotic - physiopathology Restenosis Spectroscopy, Fourier Transform Infrared Standard deviation Statistical analysis Stiffness Strength Studies Tensile tests Tension tests
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Zusammenfassung:	Abstract This study compares the mechanical properties of excised carotid and femoral human plaques and also develops a predictor of these properties based on plaque composition. Circumferential planar tension tests were performed on 24 carotid and 16 femoral plaque samples. Composition was characterised using Fourier Transform Infrared spectroscopy. Stretch at failure, strength, and stiffness are significantly higher in the carotid group ( P =.012, P
ISSN:	0021-9290 1873-2380
DOI:	10.1016/j.jbiomech.2016.09.036