Quantification of Type, Timing, and Extent of Cell Body and Nucleus Deformations Caused by the Dimensions and Hydrophilicity of Square Prism Micropillars

Novel digital analysis strategies are developed for the quantification of changes in the cytoskeletal and nuclear morphologies of mesenchymal stem cells cultured on micropillars. Severe deformations of nucleus and distinct conformational changes of cell body ranging from extensive elongation to bran...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Advanced healthcare materials 2016-12, Vol.5 (23), p.2972-2982
Hauptverfasser:	Hasturk, Onur, Sivas, Abdullah, Karasozen, Bulent, Demirci, Utkan, Hasirci, Nesrin, Hasirci, Vasif
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Body - physiology Cell Nucleus - physiology Cells, Cultured conformational changes cytoskeleton Cytoskeleton - physiology Deformation mechanisms Elongation Humans Hydrophilicity Hydrophobic and Hydrophilic Interactions Mesenchymal Stromal Cells - physiology micropillars Nuclei Nuclei (cytology) nucleus deformations oxygen plasma modification Prisms Stem cells Strategy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Novel digital analysis strategies are developed for the quantification of changes in the cytoskeletal and nuclear morphologies of mesenchymal stem cells cultured on micropillars. Severe deformations of nucleus and distinct conformational changes of cell body ranging from extensive elongation to branching are visualized and quantified. These deformations are caused mainly by the dimensions and hydrophilicity of the micropillars.
ISSN:	2192-2640 2192-2659
DOI:	10.1002/adhm.201600857