A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat

Secondary injury following traumatic spinal cord injury is induced by the activation of a number of cellular and molecular changes. RhoA, a small GTPase, regulates the organization of the actin cytoskeleton, gene expression, cell proliferation, and has been implicated in the regenerative process. Th...

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Veröffentlicht in:	Brain research 2003-01, Vol.959 (1), p.29-38
Hauptverfasser:	Sung, Joo-Kyung, Miao, Liyan, Calvert, John W, Huang, Lixin, Louis Harkey, H, Zhang, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology ADP Ribose Transferases - pharmacology Amides - pharmacology Animals Biological and medical sciences Blotting, Western Botulinum Toxins - pharmacology Enzyme Inhibitors - pharmacology Fasudil hydrochloride Female Immunohistochemistry Injuries of the nervous system and the skull. Diseases due to physical agents Intracellular Signaling Peptides and Proteins Medical sciences Motor Activity - drug effects Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proteins - analysis Pyridines - pharmacology Rat Rats Rats, Sprague-Dawley Recovery of Function - drug effects Reverse Transcriptase Polymerase Chain Reaction rho-Associated Kinases RhoA rhoA GTP-Binding Protein - metabolism RNA, Messenger - analysis Signal Transduction - physiology Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology Spinal cord injury Traumas. Diseases due to physical agents Y-27632
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Zusammenfassung:	Secondary injury following traumatic spinal cord injury is induced by the activation of a number of cellular and molecular changes. RhoA, a small GTPase, regulates the organization of the actin cytoskeleton, gene expression, cell proliferation, and has been implicated in the regenerative process. This study was undertaken to investigate the involvement of the RhoA signaling pathway in the secondary injury that follows traumatic spinal cord injury in rats. RhoA mRNA and protein expressions were enhanced significantly in the injured spinal cord 1 week after surgery ( P
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(02)03717-4